Ahhh, yet another yo-ji that speaks to the me that I wish I was... (bonus points if you can remember some of the others). And it gets us one more や行 yo-ji, which is our goal for a little while.
1. Getting away from it all (as a way of life.)
2. Living life free from worldly troubles.
I like to think of this one as having to do with a hermetic lifestyle, going off to live in the mountains, a la Spider Jerusalem, and while it wouldn't necessarily HAVE to go hand in hand with 自給自足, they would look pretty nice together, don't you think?
Try attaching の afterwards to say things like 悠々自適の生活 or 悠々自適の人生. You can get away verbing it with に過ごす or する、 but both of those usages seem less common (とくに「する」).
I moved out to the country side to start living a quiet, peaceful life away from the annoyances of the world. But trying to raise your own vegetables in the garden is actually more of a pain in the ass than being a city drone ever was.